PENGEMBANGAN SEDIAAN VITAMIN C LEPAS LAMBAT DENGAN PEMANFAATAN MATERIAL NANOSILIKA DAUN BAMBU (Bambusa sp.)

Abstract

Today, nanoparticle technology has become a trend in the development of drug supply systems such as coating, mixing and delivery of drugs. Particles or globes on a nanometer scale have typical physical properties compared to larger particles. According to Buzea (2007), some of the advantages of nanoparticles are the ability to penetrate the intercellular space that can only be penetrated by the size of the colloidal particles, the ability to penetrate the higher cell wall, and the flexibility to combine with other technologies. These advantages can be used in various shipping applications (Gelperina et al., 2005): oral (Martien et al., 2006), intravena (Li et al., 2009), pulmonar (Tonnis et al., 2012; Muttil et al., 2010), and transdermal (Ravichandran, 2009) which is in line with the pharmaceutical needs of the drug and its development. Basis of judgment in technology development for pharmaceutical therapies consists of three main factors: establishing an effective system (effectiveness), suppressing the harmful effects of the system upon use (security), and making the system acceptable to the patient (acceptance). These three considerations lead to the development of drug delivery technology. One of them is the development of nanosilicas of vitamin C from bamboo chrysanthemums through in vitro tests.The Method are  oxidation process, furnacing, washing, characterizing, making NSC and analyzing NSC. The efficacy of nanosilic-vitamin C (NSC) combination if proven, will indirectly extend half life of the body. Therefore, indirect users like NSC can reduce the frequency of drug use.