GEL HESPERIDIN DARI KULIT JERUK MANIS (Citrus sinensis L. OSBC) UNTUK PENGOBATAN ULKUS DIABETIKUM

Abstract

Diabetic ulcers is the most common caused of amputation in patients with Diabetes Mellitus (DM) based on non-traumatic occurence. The main causes of infection that occur in diabetic ulcers are caused by the bacterias such as Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Citrus sinensis L. Osbc is a potential plant that contains various chemical compounds. The rind of C. sinensis L. Osbc contains a flavanone glycoside namely hesperidin which has various pharmacological activities, one of which is as an antibacterial. Hesperidin has effectiveness as an antibacterial against several bacteria found in diabetic ulcers. Addition of culture media containing 0.5% hesperidin for 24 hours accelerated wound closure by 39% in vitro. In diabetic rats, the wound almost completely healed (97%) after oral hesperidin administration for 21 days. These showed that either hesperidin given topically or orally can accelerate skin healing in various conditions which is open wounds and closed wounds. However, hesperidin has a low solubility in water, only 2.69 mg/ml, so it is necessary to add cosolvent as a solubility enhancer, such as propylene glycol. Hesperidin gel from sweet orange peel formulated with the addition of propylene glycol can be the right choice for the treatment of diabetic ulcers because it is more practical, has a faster and more efficient effect, and can be applied directly to the ulcer. The writing method used is descriptive qualitative, a method that describes a phenomenon systematically with the results stated not in the form of numbers (non-statistics).