TERAPI PEMBERIAN SUPERFOODS BUBBLE GUM BERBASIS NANOTECHNOLOGY SEBAGAI UPAYA MENINGKATKAN QUALITY OF LIFE PADA PASIEN KANKER ANAK DENGAN KEMOTERAPI MEDIS
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Published
May 31, 2024
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Abstract
The common medical treatment for pediatric cancer patients in chemotherapy. However, it has negative psychological and physiological effects which affecting the patient’s appetite and quality of life. Referring to the two side effects caused by chemotherapy, there is one important aspect, namely awareness of the incidence of malnutrition in patients. Malnutrition conditions have very detrimental effects on patients, one of which is that the drugs given through the chemotherapy process cannot work optimally. To overcome this challenge, complimentary therapies according to the children’s preferences such as chewing gum could be provided. Chewing gum is a method of sham feeding (pretending to eat) which can stimulate appetite without complications. The aim of this scientific research is to determine the potential of providing nanotechnology-based superfoods bubble gum as an effort to improve the quality of life in pediatric cancer who medical chemotherapy. The method used in this research is an in-depth case study approach through literature study. As a result, that superfoods bubble gum is effective and has great potential to improve the quality of life of pediatric cancer patients. Chewing gum intervention is effective in reducing oral mucosity (OM) scores, increasing saliva flow, and reducing cortisol levels which have a direct effect on the patient's stress condition. In addition, this superfoods bubble gum also contains nanoparticles of Fe, vitamin A and vitamin E with a bottom-up approach to prevent micronutrient deficiencies and anemia in pediatric cancer patients. There is great hope that with multi-sector collaboration, further testing can be carried out regarding pre-clinical and clinical trials.
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References
Al Hagbani, T. and Nazzal, S., 2018. Medicated chewing gums (MCGs): composition, production, and mechanical testing. AAPS PharmSciTech, 19, pp.2908-2920.
Alvariño-Martín, C. and Sarrión-Pérez, M.G., 2014. Prevention and treatment of oral mucositis in patients receiving chemotherapy. Journal of clinical and experimental dentistry, 6(1), p.e74.
Anggreini, M.S. and Supit, D.M., 2022. Kualitas Hidup Anak dengan Kanker menggunakan Penilaian Pediatric Quality of Life Inventory di Rumah Sakit Umum Daerah Abdul Wahab Sjahranie Samarinda. Sari Pediatri, 24(3), pp.151-6.
Ardi, L., 2019. Tatalaksana Nutrisi pada Kanker Anak. Cermin Dunia Kedokteran, 46(9), pp.616-620.
Azizah, A.F., Utami, D.F. and Supatmo, Y., 2014. Pengaruh Pemberian Permen Karet Xylitol Terhadap Laju Aliran Saliva (Studi Kasus Pada Pasien Radioterapi Kepala Dan Leher Di Rsup Dr. Kariadi Semarang) (Doctoral dissertation, Faculty of Medicine Diponegoro University).
Barr, R.D., 2015. Nutritional status in children with cancer: Before, during and after therapy. Indian Journal of Cancer, 52(2), pp.173-175.
Barr, R.D., Gomez-Almaguer, D., Jaime-Perez, J.C. and Ruiz-Argüelles, G.J., 2016. Importance of Nutrition in the Treatment of Leukemia in Children and Adolescents. Archives of medical research, 47(8), pp.585-592.
Bhardwaj, T. and Koffman, J., 2017. Non-pharmacological interventions for management of fatigue among children with cancer: systematic review of existing practices and their effectiveness. BMJ Supportive & Palliative Care, 7(4), pp.404-414.
Cidon, E.U., 2018. Chemotherapy induced oral mucositis: prevention is possible. Chinese clinical oncology, 7(1), pp.6-6.
Ebrahimpour, F. and Hoseini, A.S.S., 2018. Suggesting a practical theory to oncology nurses: case report of a child in discomfort. Journal of Palliative Care, 33(4), pp.194-196.
Eghbali, A., Taherkhanchi, B., Bagheri, B. and Sedeh, B.S., 2016. Effect of chewing gum on oral mucositis in children undergoing chemotherapy: a randomized controlled study. Iranian Journal of Pediatric Hematology and Oncology, 6(1), p.9.
Febriyeni, C., Yayah, Y., Amallia, I.R. and Maulinda, D., 2023. Perbandingan Efektivitas Madu dan Permen Karet terhadap Oral Mucositis (OM) pada Anak Kanker: Literature Review. Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal, 13(4), pp.1291-1298.
Helou, M., Ning, Y., Yang, S., Irvine, P., Bachmann, L.M., Godder, K. and Massey, G., 2014. Vitamin D deficiency in children with cancer. Journal of pediatric hematology/oncology, 36(3), pp.212-217.
Hendrawati, S., Nurhidayah, I. and Mardhiyah, A., 2019. Self-Efficacy Parents in Undergoing Child Cancer Treatment at the Rumah Kanker Anak Cinta Bandung. NurseLine Journal, 4(1), pp.37-45.
Hidayati, N.O., 2017. Dampak kemoterapi pada anak penderita kanker di rumah cinta bandung. Jurnal Keperawatan'Aisyiyah, 4(2), pp.41-53.
Hrabeta, J., Eckschlager, T., Stiborova, M., Heger, Z., Krizkova, S. and Adam, V., 2016. Zinc and zinc-containing biomolecules in childhood brain tumors. Journal of Molecular Medicine, 94, pp.1199-1215.
Huerta-Yépez, S., Tirado-Rodriguez, A.B. and Hankinson, O., 2016. Role of diets rich in omega-3 and omega-6 in the development of cancer. Boletín Médico Del Hospital Infantil de México (English Edition), 73(6), pp.446-456.
Joffe, L. and Ladas, E.J., 2020. Nutrition during childhood cancer treatment: current understanding and a path for future research. The Lancet Child & Adolescent Health, 4(6), pp.465-475.
Kumar, S., Bhushan, P. and Bhattacharya, S., 2018. Fabrication of nanostructures with bottom-up approach and their utility in diagnostics, therapeutics, and others. Environmental, chemical and medical sensors, pp.167-198.
Kurniasari, F.N., Harti, L.B., Ariestiningsih, A.D., Wardhani, S.O. and Nugroho, S., 2017. Buku Ajar Gizi dan Kanker. Universitas Brawijaya Press.
Leila, B.Z., Riyana, S. and Istinengtiyas Tirta, S., 2021. STATUS GIZI ANAK DENGAN LEUKEMIA SAAT MENJALANI KEMOTERAPI (Doctoral dissertation, Universitas' Aisyiyah Yogyakarta).
Marischa, S., Angraini, D.I. and Putri, G.T., 2017. Malnutrisi pada pasien kanker. MEDULA, medicalprofession journal of lampung university, 7(4), pp.107-111.
Muhriz, M., Subagio, A. and Pardoyo, P., 2014. Pembuatan Zeolit Nanopartikel dengan Metode High Energy Milling (Zeolite Nanoparticle Fabrication using High Energy Milling Method). Jurnal Sains dan Matematika, 19(1), pp.11-17.
Nurhidayah, I., Hendrawati, S., Mediani, H.S. and Adistie, F., 2016. Kualitas hidup pada anak dengan kanker. Jurnal Keperawatan Padjadjaran, 4(1).
Obat, B.P., 2014. Peraturan Kepala Badan Pengawas Obat dan Makanan Republik Indonesia nomor 13 tahun 2014. Pedoman Uji Klinik Obat Herbal. Jakarta: Badan Pengawas Obat dan Makanan Republik Indonesia.
Ouyang, N., Lu, X., Cai, R., Liu, M. and Liu, K., 2021. Nutritional screening and assessment, and quality of life in children with cancer: a cross-sectional study in mainland China. Journal of Pediatric Nursing, 57, pp.99-105.
Pareek, V., Bhargava, A., Gupta, R., Jain, N. and Panwar, J., 2017. Synthesis and applications of noble metal nanoparticles: a review. Advanced Science, Engineering and Medicine, 9(7), pp.527-544.
Pedretti, L., Massa, S., Leardini, D., Muratore, E., Rahman, S., Pession, A., Esposito, S. and Masetti, R., 2023. Role of Nutrition in Pediatric Patients with Cancer. Nutrients, 15(3), p.710.
Racine, N.M., Khu, M., Reynolds, K., Guilcher, G.M.T. and Schulte, F.S.M., 2018. Quality of life in pediatric cancer survivors: contributions of parental distress and psychosocial family risk. Current Oncology, 25(1), pp.41-48.
RINDRIANI, D., 2019. PENGARUH MENGUNYAH PERMEN KARET TERHADAP PERISTALTIK USUS POST APPENDIKTOMI.
Rozika, R.H.M. and Purwanti, S., 2014. Eksplorasi dan Karakterisasi Sawo (Manilkara zapota (L.) van Royen) di Daerah Istimewa Yogyakarta. Vegetalika, 2(4), pp.101-114.
Santosa, A., Mulatsih, S. and Susetyowati, S., 2018. Identifikasi risiko malnutrisi dan evaluasi status nutrisi pasien kanker anak dengan pengobatan kemoterapi. Jurnal Gizi Klinik Indonesia, 15(4), pp.137-145.
Subagio, V., Wardani, N.D. and Jusup, I., 2015. Pengaruh Mengunyah Permen Karet Terhadap Tingkat Kecemasan Menghadapi Ujian (Doctoral dissertation, Faculty of Medicine).
Triarico, S., Rinninella, E., Cintoni, M., Capozza, M.A., Mastrangelo, S., Mele, M.C. and Ruggiero, A., 2019. Impact of malnutrition on survival and infections among pediatric patients with cancer: a retrospective study. Eur Rev Med Pharmacol Sci, 23(3), pp.1165-1175.
Utami, A., Allenidekania, A. and Hayati, H., 2018. INTERVENSI MENGUNYAH PERMEN KARET EFEKTIF MENCEGAH DAN MENURUNKAN DERAJAT MUKOSITIS ORAL PADA ANAK YANG MENJALANI KEMOTERAPI. Jurnal Ners Indonesia, 9(1), pp.87-96.
World Health Organization, 2024. Globocan International Agency for Reseach on Cancer. World Health Organization: Geneva, Switzerland.
Alvariño-Martín, C. and Sarrión-Pérez, M.G., 2014. Prevention and treatment of oral mucositis in patients receiving chemotherapy. Journal of clinical and experimental dentistry, 6(1), p.e74.
Anggreini, M.S. and Supit, D.M., 2022. Kualitas Hidup Anak dengan Kanker menggunakan Penilaian Pediatric Quality of Life Inventory di Rumah Sakit Umum Daerah Abdul Wahab Sjahranie Samarinda. Sari Pediatri, 24(3), pp.151-6.
Ardi, L., 2019. Tatalaksana Nutrisi pada Kanker Anak. Cermin Dunia Kedokteran, 46(9), pp.616-620.
Azizah, A.F., Utami, D.F. and Supatmo, Y., 2014. Pengaruh Pemberian Permen Karet Xylitol Terhadap Laju Aliran Saliva (Studi Kasus Pada Pasien Radioterapi Kepala Dan Leher Di Rsup Dr. Kariadi Semarang) (Doctoral dissertation, Faculty of Medicine Diponegoro University).
Barr, R.D., 2015. Nutritional status in children with cancer: Before, during and after therapy. Indian Journal of Cancer, 52(2), pp.173-175.
Barr, R.D., Gomez-Almaguer, D., Jaime-Perez, J.C. and Ruiz-Argüelles, G.J., 2016. Importance of Nutrition in the Treatment of Leukemia in Children and Adolescents. Archives of medical research, 47(8), pp.585-592.
Bhardwaj, T. and Koffman, J., 2017. Non-pharmacological interventions for management of fatigue among children with cancer: systematic review of existing practices and their effectiveness. BMJ Supportive & Palliative Care, 7(4), pp.404-414.
Cidon, E.U., 2018. Chemotherapy induced oral mucositis: prevention is possible. Chinese clinical oncology, 7(1), pp.6-6.
Ebrahimpour, F. and Hoseini, A.S.S., 2018. Suggesting a practical theory to oncology nurses: case report of a child in discomfort. Journal of Palliative Care, 33(4), pp.194-196.
Eghbali, A., Taherkhanchi, B., Bagheri, B. and Sedeh, B.S., 2016. Effect of chewing gum on oral mucositis in children undergoing chemotherapy: a randomized controlled study. Iranian Journal of Pediatric Hematology and Oncology, 6(1), p.9.
Febriyeni, C., Yayah, Y., Amallia, I.R. and Maulinda, D., 2023. Perbandingan Efektivitas Madu dan Permen Karet terhadap Oral Mucositis (OM) pada Anak Kanker: Literature Review. Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal, 13(4), pp.1291-1298.
Helou, M., Ning, Y., Yang, S., Irvine, P., Bachmann, L.M., Godder, K. and Massey, G., 2014. Vitamin D deficiency in children with cancer. Journal of pediatric hematology/oncology, 36(3), pp.212-217.
Hendrawati, S., Nurhidayah, I. and Mardhiyah, A., 2019. Self-Efficacy Parents in Undergoing Child Cancer Treatment at the Rumah Kanker Anak Cinta Bandung. NurseLine Journal, 4(1), pp.37-45.
Hidayati, N.O., 2017. Dampak kemoterapi pada anak penderita kanker di rumah cinta bandung. Jurnal Keperawatan'Aisyiyah, 4(2), pp.41-53.
Hrabeta, J., Eckschlager, T., Stiborova, M., Heger, Z., Krizkova, S. and Adam, V., 2016. Zinc and zinc-containing biomolecules in childhood brain tumors. Journal of Molecular Medicine, 94, pp.1199-1215.
Huerta-Yépez, S., Tirado-Rodriguez, A.B. and Hankinson, O., 2016. Role of diets rich in omega-3 and omega-6 in the development of cancer. Boletín Médico Del Hospital Infantil de México (English Edition), 73(6), pp.446-456.
Joffe, L. and Ladas, E.J., 2020. Nutrition during childhood cancer treatment: current understanding and a path for future research. The Lancet Child & Adolescent Health, 4(6), pp.465-475.
Kumar, S., Bhushan, P. and Bhattacharya, S., 2018. Fabrication of nanostructures with bottom-up approach and their utility in diagnostics, therapeutics, and others. Environmental, chemical and medical sensors, pp.167-198.
Kurniasari, F.N., Harti, L.B., Ariestiningsih, A.D., Wardhani, S.O. and Nugroho, S., 2017. Buku Ajar Gizi dan Kanker. Universitas Brawijaya Press.
Leila, B.Z., Riyana, S. and Istinengtiyas Tirta, S., 2021. STATUS GIZI ANAK DENGAN LEUKEMIA SAAT MENJALANI KEMOTERAPI (Doctoral dissertation, Universitas' Aisyiyah Yogyakarta).
Marischa, S., Angraini, D.I. and Putri, G.T., 2017. Malnutrisi pada pasien kanker. MEDULA, medicalprofession journal of lampung university, 7(4), pp.107-111.
Muhriz, M., Subagio, A. and Pardoyo, P., 2014. Pembuatan Zeolit Nanopartikel dengan Metode High Energy Milling (Zeolite Nanoparticle Fabrication using High Energy Milling Method). Jurnal Sains dan Matematika, 19(1), pp.11-17.
Nurhidayah, I., Hendrawati, S., Mediani, H.S. and Adistie, F., 2016. Kualitas hidup pada anak dengan kanker. Jurnal Keperawatan Padjadjaran, 4(1).
Obat, B.P., 2014. Peraturan Kepala Badan Pengawas Obat dan Makanan Republik Indonesia nomor 13 tahun 2014. Pedoman Uji Klinik Obat Herbal. Jakarta: Badan Pengawas Obat dan Makanan Republik Indonesia.
Ouyang, N., Lu, X., Cai, R., Liu, M. and Liu, K., 2021. Nutritional screening and assessment, and quality of life in children with cancer: a cross-sectional study in mainland China. Journal of Pediatric Nursing, 57, pp.99-105.
Pareek, V., Bhargava, A., Gupta, R., Jain, N. and Panwar, J., 2017. Synthesis and applications of noble metal nanoparticles: a review. Advanced Science, Engineering and Medicine, 9(7), pp.527-544.
Pedretti, L., Massa, S., Leardini, D., Muratore, E., Rahman, S., Pession, A., Esposito, S. and Masetti, R., 2023. Role of Nutrition in Pediatric Patients with Cancer. Nutrients, 15(3), p.710.
Racine, N.M., Khu, M., Reynolds, K., Guilcher, G.M.T. and Schulte, F.S.M., 2018. Quality of life in pediatric cancer survivors: contributions of parental distress and psychosocial family risk. Current Oncology, 25(1), pp.41-48.
RINDRIANI, D., 2019. PENGARUH MENGUNYAH PERMEN KARET TERHADAP PERISTALTIK USUS POST APPENDIKTOMI.
Rozika, R.H.M. and Purwanti, S., 2014. Eksplorasi dan Karakterisasi Sawo (Manilkara zapota (L.) van Royen) di Daerah Istimewa Yogyakarta. Vegetalika, 2(4), pp.101-114.
Santosa, A., Mulatsih, S. and Susetyowati, S., 2018. Identifikasi risiko malnutrisi dan evaluasi status nutrisi pasien kanker anak dengan pengobatan kemoterapi. Jurnal Gizi Klinik Indonesia, 15(4), pp.137-145.
Subagio, V., Wardani, N.D. and Jusup, I., 2015. Pengaruh Mengunyah Permen Karet Terhadap Tingkat Kecemasan Menghadapi Ujian (Doctoral dissertation, Faculty of Medicine).
Triarico, S., Rinninella, E., Cintoni, M., Capozza, M.A., Mastrangelo, S., Mele, M.C. and Ruggiero, A., 2019. Impact of malnutrition on survival and infections among pediatric patients with cancer: a retrospective study. Eur Rev Med Pharmacol Sci, 23(3), pp.1165-1175.
Utami, A., Allenidekania, A. and Hayati, H., 2018. INTERVENSI MENGUNYAH PERMEN KARET EFEKTIF MENCEGAH DAN MENURUNKAN DERAJAT MUKOSITIS ORAL PADA ANAK YANG MENJALANI KEMOTERAPI. Jurnal Ners Indonesia, 9(1), pp.87-96.
World Health Organization, 2024. Globocan International Agency for Reseach on Cancer. World Health Organization: Geneva, Switzerland.